Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .
|Published (Last):||18 September 2015|
|PDF File Size:||10.22 Mb|
|ePub File Size:||6.15 Mb|
|Price:||Free* [*Free Regsitration Required]|
She also mentioned the appearance of a small erythematous-infiltrated plaque about two centimeters in diameter at the left frontoparietal region fifteen days before the medical appointment. Total hemolytic complement CH50 was measured using the photometer, and lupus anticoagulant was evaluated by kaolin clotting time KCT.
Articles which use infobox lupuz with no data rows Infobox medical condition new All stub articles. Lupus tumidus was first described by Gougerot and Bournier in In the following years, 3 additional patients with similar skin lesions were described by the same authors 7 – 9 ; however, the next case reports of LET were not mentioned until in the German and the French literature.
The eruption had been present for one week and had occurred several months ago for a similar duration and had resolved without treatment or scarring. Once a lesion has developed, it can disappear spontaneously within a few days or weeks, even if the disease recurs chronically in patients with LET. There are few evidence-based pharmacologic treatments for LET beyond case reports luous series. These patients were placed on the same antimalarial therapy and again achieved remission within 12 weeks.
This, tumiduss, places our patient at risk for adverse drug reactions such as retinopathy or agranulocytosis with hydroxychloroquine therapy.
The same group reported interstitial mucin deposition as a further characteristic feature of LET and results of direct immunofluorescence staining as often being negative; however, there was no doubt about LET being a separate subset of CCLE.
However, other cutaneous manifestations such as hypopigmentation, mucous membrane ulcers, diffuse alopecia, livedo reticularis, or vasculitis have never been seen in any of the patients. SLE may also affect joints, kidneys, lungs, heart, liver, brain, blood vessels vasculitis and blood cells.
Cutaneous lupus erythematosus
LE nearly always affects the skin to some degree. In contrast to LET, histological features of Jessner’s lymphocytic infiltration of the skin show no interstitial mucin deposition, but varying numbers of plasma cells may be present. For sex distribution, patients with LET were compared with the control group of patients with other forms of cutaneous LE observed at our department from January 1,through December 31,consisting of 66 male and female patients.
Views Read Edit View history. Because of the rapid and effective improvement of the skin lesions after treatment with antimalarials, systemic corticosteroids or immunosuppressants were temporarily necessary in only 2 patients. J Am Acad Dermatol. A general stepwise approach to treatment can be partially extrapolated from Kuhn, et al’s, series of 40 patients from a progressively more systemic and toxic lineation; sunscreen sun exposure avoidancetopical steroid treatment, antimalarial therapy, followed by systemic steroids, and other immunosuppressants.
Criteria for positive provocative phototest results required that induced lesions clinically resembled LE, histopathological findings were compatible with LE, and skin lesions developed slowly and persisted for several days or weeks in contrast to other photodermatoses such as PLE.
LET resolves with normal skin, no residual scarring, no hyperpigmentation lupjs hypopigmentation. Vasculitis and antiphospholipid syndrome involving internal organs can be serious. Increased dermal mucin was noted and confirmed by a colloid iron stain Figure 4. InGoerz et al 16 emphasized the extreme photosensitivity as a major characteristic feature of LET and detected a male predominance with the peak of onset from 41 through 50 years of age.
Results of histological examination show perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition. Intermittent cutaneous lupus erythematosus.
Footnotes Conflict of Interest: National Center for Biotechnology InformationU. Histopathologic findings in lupus erythematosus tumidus: The diagnosis of lupus tumidus is usually delayed, as it can be confused with other dermatoses due to the absence of systemic manifestations. A year-old female patient presented with a complaint of lesion on the thorax for 4 months. Med Clin North Am. Specific features of acute cutaneous LE may include:.
Received Jul 17; Tumidsu Oct The prognosis for cutaneous LE is variable. Updated in January A mildly elevated creatinine level from Purchase access Subscribe to the journal. Clinical and histopathological findings confirmed our hypothesis of lupus tumidus. Twenty-two patients achieved complete or almost complete remission.
Tumid lupus erythematosus – Wikipedia
Active and burned-out disease can lead to social isolation and depression. Tumid lupus erythematosus also known as “lupus erythematosus tumidus”  is a rare, but distinctive entity in which patients present with edematous erythematous plaques, usually on the trunk.
Hyperkeratosis, slight epidermal hyperplasia, and sunburn cells were observed in some of the UV-induced skin lesions. The infiltrate was composed of lymphocytes, histiocytes, plasma cells, and a few scattered neutrophils.
The main differential diagnoses are polymorphous light eruption, Jessner’s lymphocytic infiltration tumidue the skin, reticular erythematous mucinosis, and pseudolymphoma.