FORMULATION AND EVALUATION OF EMULGEL PDF

Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.

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A set of nine rats was used in the study. The drug release was found to be Different formulations F1-F4 of Oxiconazole emulgel was prepared by using carbopol as gelling agent with varying concentrations of oily phase such as liquid paraffin and Tween and Span as a emulsifying agent.

A total of 6 rats were used in each group, for placebo, marketed gel and aceclofenac formulated emulgel, amounting to 18 rats in total. The oxiconazole used in treatment of various fungal infections such as cutaneous and subcutaneous diseases like acne and psoriasis. Microemulsion formulation for enhanced absorption of poorly soluble drugs: Saturation solubility of aceclofenac in various oils, surfactants, co-surfactants was determined by saturation solubility method.

Evaluqtion allergic symptoms like inflammation, redness, irritation appeared on rats up to 24 h.

The resultant microemulsion and emulgel both exhibited the evalutaion drug release in-vitro and ex-vivo. All other chemicals and solvents were of analytical reagent grade.

F1 and F2 with 0. The developed emulgels were evaluated for their physicochemical properties like color, homogeneity, consistency, spreadability, pH value, rheological behavior, drug content, drug release and stability. The average cumulative amount of drug permeated per unit surface area of the skin was plotted versus time. Absorbance was measured after suitable dilution at nm using UV-Vis spectrophotometer.

Formulation and evaluation of oxiconazole emulgel for topical drug delivery

Previous studies have attempted formulation of aceclofenac in emulgels and gels, however, the data regarding formulation of microemulsion-based emulgel of aceclofenac and head-to-head comparison of anti-inflammatory activity with the most popular marketed emulgel is not reported in the literature 15 – So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

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Additionally, microemulsions have improved stability 12 – A similar effect was observed with the marketed diclofenac formulation, which reinforces the proof of efficiency of the emilgel gel in delivering diclofenac and reducing inflammation. It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus MRSA infections.

Formulation development and characterization of microemulsion drug delivery systems containing antiulcer drug. Different concentrations of carbopol were taken for trials and the optimum emulgel formulation was selected Table 1 and Fig. Similar investigation by Pottalaswathi and Vema 18reiterated these findings that incorporation of Carbopol in an emulgel of aceclofenac improves its penetration Hence, the topical route would be one of the ideal alternatives emjlgel enhance local delivery, bypassing these side effects.

Formulation and Evaluation of Tioconazole Emulgel for Topical Drug Delivery System

Based on the results of solubility studies, Isopropyl myristate, Adn 80 and Ethanol were chosen as oil, surfactant and co-surfactant, respectively. A formulation yielding clear and transparent appearance and the one not cracking when observed for 24 h was selected for further studies. The receptor chamber was filled with freshly prepared phosphate buffer pH 6. The study also highlights preclinical analysis, that aceclofenac and diclofenac show equal efficacy when used topically.

Additionally, a study conducted by Patel et al. The anti-inflammatory activity was numerically more in voltaren emulgel as compared to aceclofenac emulgel. The study revealed that the formulation with carbopol shown better release profile than HPMC K4M, depicting carbopol as the better choice of polymer for aceclofenac emulgel.

An emergent tool in topical drug delivery. Anti-inflammatory studies by carrageenan induced evqluation edema model: The particle size formulafion the microemulsion was found to be The anti-inflammatory activity of aceclofenac emulgel was evaluated using croton oil induced ear edema against acute inflammation. The aliquots 1 mL were collected at time intervals of 1 h up to 8 h. Topical drug administration is simplest and easiest route of localized drug delivery anywhere in the body by routes as ophthalmic, rectal, vaginal and skin.

Group I was diseased control, group II received dose of 25 mg of aceclofenac emulgel whereas group III received marketed diclofenac emulgel. In this evaluatlon, the study provides a preliminary comparative efficacy data for both the drugs, providing a foundation for a robust clinical evaluation in future studies. The drug release was found to be higher for optimized formulation as compared to the marketed Terbinafine hydrochloride cream.

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The solubility of aceclofenac in different oils, surfactants and co-surfactants was determined since it is the most important criteria for microemulsion preparation Table 2. Carrageenan induced paw edema model: Thus, the microemulsion base improved the solubility of the drug and the emulgel formulation enhanced the delivery in a sustained manner.

The study yields novel insights into the formulation strategies for designing a water soluble novel drug delivery system of an anti-inflammatory, low-solubility drug aceclofenac. Samples were analyzed for drug content by UV-Vis spectrophotometer after appropriate dilutions. The anti-inflammatory activity of aceclofenac emulgel was evaluated using carrageenan induced paw edema in rats by a method described by Gerald et al.

Please feel free to contact me if you have any questions or comments. After a number of trials, microemulsion of aceclofenac was optimized with:. Moreover, the effectiveness of the formulation in delivering the drug as manifested in vitro and ex vivo studies, was transposed into significantly mitigating inflammation in animal models.

FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE EMULGEL

February 21, ; Accepted: Invited for research articles. By the In-vitro diffusion studies it was observed that formulation F1 showed Microemulsion containing 15 mg of aceclofenac was evenly applied onto the surface of dialysis membrane along with aceclofenac suspension in water for comparison. The solubilization capability of aceclofenac in different oils, surfactant and co surfactant was shown in the Table 1.

Search in Google Scholar. Voltaren emulgel produced maximum inhibition of Compared with ointments and creams, gelsprovide a better feel are greaseless and easily washable.

It combines dual release pattern of both gel and emulsion providing better therapeutic action and sustained release 34.